Ozone Therapy: A Natural Approach to Boosting Immunity

Ozone therapy exerts its immune-boosting effects through several mechanisms:

1. Enhanced ATP Production: Ozone therapy improves the glycolytic pathway in red blood cells (erythrocytes), leading to a significant increase in ATP (adenosine triphosphate) content. ATP is the primary energy source for cellular functions, including immune responses. By increasing ATP production, ozone therapy supports optimal energy metabolism in immune cells, enhancing their activity and overall immune function.
2. Improved Oxygen Release: Ozone therapy stimulates the hexose-monophosphate shunt and activates 2,3-DPG mutase, resulting in the conversion of 1,3-DPG to 2,3-DPG. This shift causes a rightward shift of the hemoglobin dissociation curve, enhancing the release of oxygen in hypoxic (low oxygen) tissues. Improved oxygenation supports immune cells’ ability to function optimally and enhances tissue healing.
3. Vasodilation and Blood Flow: Ozone therapy improves vasodilation in ischemic (restricted blood flow) areas. It enhances the release of vasodilators, possibly including prostacyclin (PG2) COX 2, which promotes the dilation of blood vessels and improves blood flow. By enhancing blood circulation, ozone therapy ensures optimal delivery of oxygen and nutrients to tissues, supporting immune cell activity and overall immune response.
4. Antioxidant Activity: Ozone therapy enhances the antioxidant status of the body by activating the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). Nrf2 binds to antioxidant response elements (ARE) on DNA, promoting the transcription of various antioxidative enzymes. This activation helps counteract chronic oxidative stress, maintain cellular redox balance, and reduce inflammation. Ozone therapy also stimulates the release of heme oxygenase-1 (HO-1), which contributes to reducing inflammation and supporting antioxidant defense.
5. Neuro-Endocrine Stimulation: Ozone therapy has been observed to stimulate the neuro-endocrine system, leading to a feeling of wellness in patients throughout the therapeutic sessions. This stimulation may involve the release of neurotransmitters, hormones, and other signaling molecules that positively influence immune function. A sense of well-being can further contribute to stress reduction and overall immune enhancement.
6. Immunomodulation: Ozone therapy has immunomodulatory effects, meaning it helps balance and regulate immune responses. It can stimulate the production of cytokines, such as interferon and interleukins, which play crucial roles in immune cell communication and activation. By modulating the immune system, ozone therapy helps optimize immune responses, leading to improved defense against infections and diseases.