Is Ozone Therapy Safe? Risks, Side Effects & Safety in India

Published on: 28/Aug/2025
Posted By: Arka Health

Introduction

Ozone therapy is rapidly gaining attention as a powerful tool in integrative and functional medicine. From boosting immunity to aiding in chronic illness recovery, its potential benefits are creating a significant buzz. Yet, with this growing interest comes a crucial and entirely valid question: Is ozone therapy safe?

For many residents exploring innovative health solutions, understanding ozone therapy safety in Bengaluru is the first and most important step. You may have heard conflicting information, that ozone is a toxic gas, or that the therapy is unregulated. These are serious concerns that deserve a clear, evidence-based answer.

At Arka Anugraha Hospital (Arka Health) in JP Nagar, we believe patient empowerment begins with transparent information. As a pioneering center for functional and integrative medicine in South Bangalore, we are committed to providing therapies that are not only effective but are administered with the highest standards of safety. This guide will demystify the risks, side effects, and safety protocols surrounding medical ozone therapy in India, so you can make an informed decision about your health.

The Ozone Paradox: How Can a "Toxic" Gas Be Therapeutic?

One of the biggest sources of confusion about ozone therapy stems from a misunderstanding of what “ozone” is in a medical context. We often associate ozone with air pollution or the protective ozone layer in the atmosphere. Indeed, inhaling atmospheric ozone is harmful and can cause significant respiratory damage. 

This is the critical point: Medical ozone is never inhaled. 

Medical ozone therapy uses a precisely controlled mixture of pure, medical-grade oxygen (about 95-99.95%) and a very small, therapeutic concentration of ozone (0.05-5%). This mixture is administered by trained medical professionals through established methods that bypass the lungs entirely.

The therapy works on a fascinating biological principle known as hormesis. When a small, controlled dose of medical ozone is introduced into the body, it creates a mild, transient oxidative stress. This controlled stressor acts as a powerful signal, essentially “waking up” your cells and prompting them to activate their own powerful, built-in defense and repair systems.  This process helps to:

  • Reduce inflammation 
  • Improve oxygen delivery to tissues 
  • Modulate the immune system 
  • Activate the body’s own antioxidant defenses 

Safety, therefore, is not about the substance itself, but about the dose, method, and expertise with which it is administered.

The Scientific Evidence for Ozone Therapy's Safety Profile

When performed correctly, medical ozone therapy has an exceptionally strong safety record, backed by decades of clinical use and extensive research.

A landmark German study published in 1980 surveyed 644 therapists regarding over 5.5 million ozone treatments administered to 384,775 patients. The study found an incredibly low side-effect rate of just 0.000007%, making it one of the safest medical therapies known when performed according to established protocols. 

To ensure this high level of safety is maintained globally, practitioners follow strict international guidelines. The most important of these is the Madrid Declaration on Ozone Therapy, a global consensus document that outlines best practices, safe therapeutic concentrations, and recommended routes of administration. Professional bodies in India, such as the Ozone Forum of India, are signatories to this declaration, committing to uphold these international safety standards.

A Clear Look at Ozone Therapy Side Effects in Bangalore

Like any medical procedure, ozone therapy can have side effects. However, when administered by a trained professional, they are typically mild, temporary, and predictable.

Common and Mild Side Effects

Most side effects are minor and resolve on their own. These can include:

  • Mild Fatigue or Drowsiness: Some patients feel tired or sleepy for a short time after a session. 
  • Headache or Dizziness: A slight headache or feeling of dizziness may occur but usually passes quickly. 

Herxheimer Reaction: Sometimes referred to as a “healing crisis,” this can manifest as temporary flu-like symptoms. This is often considered a positive sign that the therapy is working to eliminate pathogens and toxins from the body.

Understanding and Avoiding Rare but Serious Risks

The more serious ozone therapy risks you may read about are almost always linked to improper administration or outdated techniques that are strictly prohibited by international guidelines and are not used at professional centers like Arka Health.

    • Air Embolism: This is a dangerous blockage of a blood vessel by a gas bubble. This risk is associated only with the outdated and condemned practice of direct intravenous (DIV) injection of ozone gas. Modern, safe ozone IV therapy in Bangalore uses a method called Major Autohemotherapy (MAH). In MAH, a small amount of your blood is drawn, mixed with ozone in a sterile container outside the body, and then safely reinfused. This closed-loop system eliminates the risk of air embolism. 
    • Lung Damage: This risk is exclusively associated with inhaling ozone gas. As stated before, this is never a route of administration in a clinical setting. 
    • Infection: As with any procedure involving injections, there is a minimal risk of infection. This is mitigated by adhering to strict sterile protocols, using single-use disposable materials, and performing the therapy in a clean, clinical environment. 

Who Should NOT Have Ozone Therapy? A Guide to Contraindications in India

While ozone therapy is safe for most people, it is not suitable for everyone. A thorough medical evaluation is essential to ensure it is the right choice for you. The absolute ozone therapy contraindications in India and worldwide include:

  • G6PD Deficiency (Favism): A rare genetic enzyme deficiency that can cause red blood cells to break down under oxidative stress. 
  • Pregnancy: The therapy has not been sufficiently tested in pregnant patients. 
  • Active and Uncontrolled Bleeding: Or any severe bleeding disorder like thrombocytopenia or hemophilia. 
  • Uncontrolled Hyperthyroidism: An overactive thyroid condition. 
  • History of Seizures or Convulsions: 
  • Recent Heart Attack or Stroke: It is generally advised to wait at least six months after an acute event.
  • Acute Alcohol Intoxication: At Arka Health, our functional medicine approach includes a comprehensive initial consultation to screen for these conditions and ensure patient safety above all else.

The Regulatory Landscape: Is Ozone Therapy Safe and Legal in India?

The question of ozone therapy regulation in India is important. Currently, medical ozone therapy is not officially regulated as a mainstream treatment by national bodies like the Central Drugs Standard Control Organisation (CDSCO) or the Indian Council of Medical Research (ICMR). However, this does not mean it is illegal or unsafe.

The practice is guided and self-regulated by professional organizations, chief among them being the Ozone Forum of India (OFI). The OFI, an initiative of the Bisleri Charitable Trust, is dedicated to the education, research, and safe practice of ozone therapy in the country. They have trained thousands of doctors across India, ensuring that practitioners adhere to standardized, internationally recognized protocols. 

Furthermore, the Ministry of AYUSH has shown increasing interest in collecting clinical research data on the therapy, signaling a move towards greater institutional recognition in the future. While the US FDA has issued warnings against ozone therapy, it’s important to note that this stance is not universally shared, and the therapy is recognized and regulated in many countries across Europe and Asia.

How to Ensure Ozone Therapy Safety in Bengaluru: The Arka Health Standard

Your safety is the most critical factor. Choosing the right provider is paramount. If you are looking for safe ozone therapy centers in Bangalore, especially in South Bangalore areas like JP Nagar, Jayanagar, BTM Layout, Banashankari, or near Bannerghatta Road, here is what you should look for and what we guarantee at Arka Health:

Qualified and Certified Practitioners:

The therapy must be administered by a trained medical doctor. At Arka Health, our treatments are overseen by experts like Dr. Gaurang Ramesh, a functional medicine practitioner who integrates ozone therapy into a holistic, root-cause-focused treatment plan.

Adherence to International Protocols:

We strictly follow the safety guidelines of the Madrid Declaration on Ozone Therapy, ensuring every procedure meets the highest global standards.

Medical-Grade Equipment:

We use certified medical-grade ozone generators that produce a pure ozone-oxygen mixture from medical-grade oxygen. This allows for precise control over concentrations, which is critical for both safety and efficacy.

Comprehensive Patient Screening:

Before any treatment, we conduct a thorough consultation and medical history review to identify any contraindications and ensure the therapy is appropriate for you.

A Holistic, Integrative Approach:

Safety is enhanced when the practitioner understands your complete health picture. Our functional medicine ozone therapy in JP Nagar is part of a larger wellness strategy that addresses factors like gut health, nutrition, and chronic inflammation, ensuring the treatment supports your entire system.

Conclusion: Making an Empowered and Safe Choice for Your Health

The evidence is clear: when administered by a trained medical professional according to established protocols, medical ozone therapy has a remarkable safety profile. The most significant risks are associated with outdated and improper techniques that are strictly avoided in professional settings like Arka Anugraha Hospital.

By choosing a clinic that prioritizes practitioner expertise, uses medical-grade equipment, and follows international safety guidelines, you can confidently explore the benefits of this innovative therapy.

If you are ready to learn more about ozone therapy safety in Bengaluru and discover if it can be a part of your wellness journey, we invite you to our state-of-the-art facility in JP Nagar.

Contact Arka Health today to schedule a consultation with our integrative medicine experts. Let us answer your questions and help you take the next safe step towards optimal health.

Frequently Asked Questions (FAQ)

Q1: What are the most common side effects of ozone therapy in Bangalore?

The most common side effects are mild and temporary. Patients may experience slight fatigue, a mild headache, or a brief flu-like “healing crisis” as the body detoxifies. These symptoms typically resolve within a few hours to a day.

Q2: Is ozone IV therapy safe?

Yes, when performed correctly using the Major Autohemotherapy (MAH) method. This involves drawing your blood, mixing it with ozone in a sterile bag, and re-infusing it. This method is very safe. The dangerous practice of injecting ozone gas directly into a vein (Direct IV or DIV) is considered malpractice and is never performed at Arka Health or any other reputable clinic.

Q3: How do I know if an ozone therapy clinic is safe?

Look for a clinic that is run by certified medical doctors who are trained in ozone therapy (ideally affiliated with the Ozone Forum of India). They should use a medical-grade ozone generator, follow international safety protocols like the Madrid Declaration, and conduct a thorough medical screening before starting any treatment.

Q4: Is ozone therapy approved by the Indian government?

Ozone therapy is not officially regulated as a mainstream treatment by central bodies like the CDSCO or ICMR. However, it is not illegal and is widely practiced as a complementary therapy. Its practice in India is guided by professional organizations like the Ozone Forum of India, which sets standards for training and safety. The Ministry of AYUSH is also collecting clinical data on its use, indicating growing recognition.

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